Chapter 38 A box of tyrosine kinase inhibitor worth 24,000 yuan

"Guan Ju, let me give you some keywords and see if you can analyze what the disease is."

"Let me try."

"The key words are: chromosomes 9 and 22, encoding P210, P230 and P190 proteins, as well as Bcr fusion genes and so on."

Xu Nuo told Guan Ju some of the key words on the piece of paper that he had memorized.

"BOSS, according to my analysis, this should be a balanced translocation of the patient's long arms of chromosomes 9 and 22, resulting in the formation of the Ph chromosome, resulting in the formation of the Bcr-Abl fusion gene, because the Bcr-Abl fusion gene codes for P210.

P230 and P190 fusion proteins interfere with the normal physiological functions of cells, leading to excessive cell proliferation and inhibition of apoptosis, leading to chronic myelogenous leukemia."

"Chronic Myelogenous Leukemia!"

Xu Nuo was shocked when he heard this.

It turned out that assistant Wen Ruohan went to the hospital for a check-up and was diagnosed with chronic myelogenous leukemia.

No wonder she looks different these days, she has lost all her lively and cheerful energy.

"How could such a young girl get such a disease?"

Wen Ruohan asked doubtfully.

But Xynotox does not have the ability to develop drugs.

But Wen Ruohan's current monthly salary is only a little over 10,000, and the rest has to be paid at home, but he has to eat one box a month. Even a well-off family will be dragged down by this disease.

.

Without huge biomedical knowledge as a basis, even if we exchange new drug technology for tyrosine kinase inhibitors from the system, it will be a castle in the air.

"How much does it cost in China?"

The next second, Xu Nuo pulled out the system panel.

"BOSS, because there are many patients with chronic myelogenous leukemia in China and the number is increasing year by year, the negotiations between the European Nori Pharmaceutical Group and domestic medical insurance have been deadlocked and have failed to make any progress, and there is little hope in the future."

When Xu Nuo was on earth in his previous life, he felt deeply after watching the movie "I'm Not the God of Medicine".

"Smiling face, right?"

While Xu Nuo was thinking about it, assistant Wen Ruohan entered the office.

It seems that if I want to acquire more black technologies in the future, I will have to make more movies to earn entertainment points.

"The "Terminator" has completed the 2 billion box office task and can obtain +5 entertainment points. As of today, the real-time box office of "Terminator" is 1.271 billion yuan."

Xu Nuo still remembers a sentence in the movie "I'm Not the God of Medicine" in his previous life on Earth. It roughly means that no matter what family, if they get this chronic myelogenous leukemia, the final result will be to keep taking medicine and then sell their house and car, and the family will be destroyed.

.

Therefore, Xu Nuo does not plan to develop drugs by himself, but he can let his own company do it. Then the company needs a medical laboratory, a group of top students in biomedical research and development, and a sum of funds.

"Is that so? Are there any generics of imatinib mesylate available in China?"

"Hehehe, boss, this is what I should do."

"The price is 24,000 yuan per box. One box is one course of treatment. Generally, patients need to maintain one course of treatment per month."

Guan Ju: "Patients with chronic myeloid leukemia account for about 15% of leukemia patients, and there are about four million leukemia patients in my country, so the number of chronic myeloid leukemia patients is about 600,000."

She has now put away her depressed mood, showing the same optimistic and cheerful personality as before, and she also has a smile on her face, because she knows that she still has to be active when working in the company.

"Twenty-four thousand per box, and without medical insurance, who can afford this?"

Xu Nuo nodded, and then couldn't help but glance at Wen Ruohan: "Xiao Wen, you."

Xu Nuo couldn't help but sigh, and then asked: "What is the most effective drug in the world for treating chronic myelogenous leukemia?"

"Domestic patients with chronic myelogenous leukemia tend to be younger than overseas, but the age of onset is usually 40-50 years old. It is indeed rare for people like Wen Ruohan to get sick in their early twenties."

"It's okay, I was just thinking that you have been doing a good job since you joined the company. When I was filming "Terminator", you also completed various daily tasks for me with the crew. I can see your efforts.

"

Xu Nuo suddenly thought of "I'm Not the God of Medicine".

No wonder I always think this leukemia sounds familiar.

"It's so expensive, isn't it covered by our domestic medical insurance?"

This is completely inconsistent with Xu Nuo's profession.

Xu Nuo asked.

"Imatinib mesylate, a tyrosine kinase inhibitor drug developed by Europe's Nori Pharmaceuticals Group, is currently the world's mainstream targeted drug for the treatment of chronic myelogenous leukemia."

"Aren't there any pharmaceutical companies in our country that are developing domestically produced tyrosine kinase inhibitor drugs?"

Even Guan Ju's tone of reply contained a hint of regret.

"Put it here."

After thinking about it, Xu Nuo decided not to tell Wen Ruohan about her suffering from chronic myelogenous leukemia for the time being. After all, this matter had a great impact on her.

"Boss, what's wrong?"

Guan Ju: "Selling generic drugs is illegal. According to online information, many groups have sold generic imatinib mesylate drugs in the past, but they were quickly brought to justice."

Xu Nuo felt such a pity.

Naturally, Xynotox will not sell generic drugs.

Xu Nuo first put this idea into his plan.

"Guan Ju, how many patients with chronic myeloid leukemia are there in the country?"

"It will take a few days to get these 5 entertainment points, but it doesn't matter. Research and development of drugs itself takes a long time."

As long as you insist on taking medicine, this disease can remain stable and be no different from normal people.

Biomedicine and human health are also promising fields of science and technology.

"This biomedical technology - [new generation tyrosine kinase inhibitor] requires 2 entertainment points to redeem. How many entertainment points can I get after my movie "Terminator" completes the box office mission of 2 billion?

"

Xu Nuo asked his system.

"So many. Sigh."

Even if I want to work on chronic myelogenous leukemia and make a movie called "I'm Not the God of Medicine," that would be to develop our own domestically produced tyrosine kinase inhibitor drugs.

Guan Ju explained it to Xu Nuo.

Xu Nuo touched his chin and began to think about it.

Xu Nuo shook his head after hearing this.

Especially his assistant Wen Ruohan, who originally followed him and had a bright future, but now it seems that all his beautiful illusions have been shattered by this disease.

Guan Ju replied.

"Chronic myelogenous leukemia. Is it the disease in "I'm Not the God of Medicine"?"

"Boss, here is your itinerary for the Rabbit University of Science and Technology and the City Science and Technology Expo." Wen Ruohan handed the prepared itinerary to Xu Nuo.

The only problem is that for patients, the financial pressure is too great. After all, a box of imatinib mesylate tablets produced by the European Nori Pharmaceuticals Group costs 24,000 yuan.

Wen Ruohan laughed happily when her boss praised her ability again.

This drug is extremely expensive in China. If ordinary people are diagnosed with chronic myelogenous leukemia and want to survive, they will really lose their money.

Xu Nuo glared at assistant Wen Ruohan, and then said: "Now our "Terminator" box office performance is good, the company has several new orders, everything is booming in a good direction, so I thought

I'm going to give you a salary increase soon."

“Due to the long drug development cycle, high costs, and high risks, domestic pharmaceutical companies have not conducted in-depth research and development of tyrosine kinase inhibitor drugs. Patients can only purchase imatinib mesylate from European Nore Pharmaceutical Group.

.”

"Wow, that's a salary increase, is it true, boss?"

Wen Ruohan became even more excited when she heard that her boss wanted to increase her salary.

"Can I still give you some advice? Your salary is now 12,000, right? I'll give you another 3,000."

"Thank you boss, I feel more energetic at work (*^▽^*)"
Chapter completed!