Removed the specimen from the human body and Lu Li walked out of the operating room.

When he came to a test bench next to him, Lu Li sat down and started to edit T cells.

Gene editing and modification, this technology has long appeared.

Genetic modifications of natural means include fruit tree grafting technology, and even hybrid rice technology that is familiar to people. These are gene modification technologies.

People are also familiar with gene editing and modification of unnatural means, such as...GMO technology.

Even if you are tampering with human genes, it will not be once or twice.

As early as 2016, a guy named He Jiankui made a pair of gene-edited babies called "immunized to AIDS" on human embryos, and then... He Jiankui was arrested and went to jail!

When the technology is completely immature, a pair of gene-edited babies was actually created. Is this a bit of a scientist's conscience and morality?

If genetic technology is a way of heaven, humans have just taken a small step, and they want to play God? How stupid and arrogant is this?

The more developed human science and technology is, the more we must maintain a sense of awe.

Lu Li sat in front of the test bench and carefully took out a little cancer cell specimen and installed it under an electron microscope.

In the image of an electron microscope, the internal structure of the cell is clearly presented on the display screen.

The endoplasmic reticulum, ribosome, Golgi body, lysosome, mitochondria, microsome, vacuole, cytoskeleton, cytosol, and even DNA wrapped inside the cell nucleus are clearly presented.

DNA needs an electron microscope to see, but... if you straighten it, the DNA chain is more than two meters long.

Manipulating the instrument and injecting Cas9 transcriptase into cancer cells with a gene gun. Lu Li clearly saw that the transcriptase was close to the DNA chain and copied a piece of DNA information.

The transcription of cancer cell gene information is completed.

Lu Li started to do the next experiment again. Install T cells under an electron microscope, and Lu Li used a gene gun to inject cancer cell gene information into T cells.

Soon, T cells absorbed this genetic information and included it in the "hostile sequence" of the immune system.

By doing this, weapons against cancer cells have been prepared.

But... Once injected into the human body, the T cells will divide wildly, which will inevitably lead to the immune system going crazy, and will kill me regardless of the enemy.

The result is that before the cancer kills the person, the immune system will kill the human body first.

Therefore, Lu Li needs to perform one more step.

This time, Lu Li is preparing to modify the "information dissemination mechanism" of T cells so that it will no longer summon "air support" or "calling friendly forces" everywhere, but only let it fight alone.

Perhaps, this may not cause the immune system to go crazy.

This involves another gene editing technology, CRISPR-Cas9.

This gene editing technology originates from the mutation mechanism of bacteria against bacteriophages.

When bacteria fight phage attacks, they will mutate a special protein, which can cut off the gene chains injected into the cell nucleus.

It has to be mentioned here that bacteriophage is the most terrifying killer in this world.

Every moment, a war that has lasted for countless years is breaking out in every corner of the world. The scale of the war has reached a terrifying order of 100 million magnitude.

This is the attack on bacteria by phages.

Bacteriophage is a virus with a very regular appearance. It has a twenty-sided dice on its head, a torso like a small stick, and a few spider legs below it, just like a nanorobot.

Phages are harmless to the human body, they just attack bacteria frantically. They inject their own DNA into bacteria and partially split into countless phages in the cells, thereby killing bacteria and spreading continuously.

In the face of phage attacks, bacteria have also evolved a means of resistance, which is a special protein mentioned above. This protein will cut off the DNA injected by phages.

Humans use this special protein to achieve the purpose of cutting genes, modifying genes, and even editing genes.

In the laboratory, Lu Li repeated the experiment of phage attacking bacteria and obtained the special protein CRISPR, which bacteria used to fight phages.

Then, this CRISPR protein is combined with Cas9 transcriptase and injected into T cells to modify the genes of T cells.

Genetic location is a problem.

Lu Li did countless experiments in a row, but failed to obtain accurate gene modification results.

Even if transcriptases do gene match, the shearing proteins often cut into the wrong places.

It is not just a scissor to cut it. This extremely microscopic operation cannot penetrate the nucleus of any tool, and it can only be achieved by shearing proteins.

Fortunately, the gene matching of transcriptase is still in play.

After repeating the experiment hundreds of times, I finally got the right place.

A T cell that has been gene-edited was finally born.

Lu Li quickly stood up and injected the T cell into the virtual human body.

Then it's waiting!

After gene editing, after entering the human body, the T cells immediately detected the existence of "hostile target" cancer cells, instantly activate the stress mechanism, began to absorb human nutrients, and split wildly.

Half an hour later, the human body began to have a fever and the heart rate increased sharply.

This is the immune mechanism that works. The symptoms of fever are the normal mechanism of the immune system to cope with virus invasion.

Then…the immune system is still going crazy!

Even if T cells do not "call friendly forces", the T cells' army will still cause the human body to have a violent immune response, and the "factor storm" still occurs.

But...it seems to be less serious.

Lu Li quickly released drugs to control the crazy immune system to maintain the vital signs of the human body.

Heart-strengthening injections, adrenal hormones, first aid, and various emergency measures have been put into operation. I don’t know how long it took, but this experimental human body finally stabilized.

"Sure enough, my idea is right!"

Lu Li let out a long breath and grinned, "Eliminating the ability of T cells to call friendly forces can reduce the chance of the immune system going crazy."

Although this little progress cannot make CAR-T cancer treatment technology a key breakthrough, but as a graduate paper, the value is absolutely sufficient.

After closing the virtual laboratory, Lu Li opened his eyes and another night passed.

After getting up, I washed up, went out for breakfast, Lu Li returned home, sat in front of the computer, and started writing the paper.

"A preliminary exploration of the mechanism of CAR-T technology blocking T cell information transmission!"

Lu Li sat at the computer desk, his hands pounding on the keyboard, and a paper with detailed data, clear experimental steps, and real and reliable is easily written.

One piece of Chinese and one piece of English, all done.

Then, Lu Li called Professor He, "Teacher, my research topic has already..."

"I've already figured out the topic? It's very efficient!"

Before Lu Li finished speaking, Professor He took over the conversation, "Okay, send me the topic! I'll report it to you."

"That... is not a topic, it is a paper. I wrote a paper."

Lu Li quickly explained: "Teacher, I wrote a paper and sent it to your email address. Please correct me!"

"paper?"

Professor He was stunned for a moment. You wrote a paper without even choosing a topic? Could it be that kind of essay that makes you famous?

"I'll take a look!"

Professor He didn't say much, and was going to read it first. If it was really a paper, then we had to deal with Lu Li and kill this unhealthy trend.

Sitting back to the office desk, Professor He turned on the computer and saw the paper sent by Lu Li in his email.

When he clicked on the paper and saw the title "CAR-T technology, preliminary exploration of the mechanism of blocking T cell information transmission", Professor He was stunned.

CAR-T technology? This is still a world-class scientific research project!

Screen T cell information dissemination mechanism? New gene editing technology?

Professor He suddenly looked solemn and he quickly looked at it seriously.

The paper was in duplicate, one in Chinese and one in English. Professor He was too lazy to read the English version, so he picked up the Chinese version of the paper and started reading it.

The whole paper is not very moisture-free, it is all dry goods.

In the paper, Lu Li described the new gene editing direction of T cells in detail, each step is clear and the experimental data is very detailed.

Judging from the paper, as long as Lu Li's experimental steps are followed, this gene editing technology that blocks the T cell information transmission mechanism can be completely repeated.

From a theoretical analysis, blocking the information transmission mechanism of T cells can indeed effectively reduce the "factor storm" and reduce the chance of the immune system going crazy.

"This kid... was silent and actually made a thunderbolt for me!"

Professor He had a bright smile on his face, "The breakthrough in CAR-T technology is a major scientific research result! Not bad! Not bad!"

After reading this paper, Professor He quickly downloaded the paper and printed it out. Then, Professor He picked up the paper materials, turned around and ran out.

I came to the Cancer Research Office of Fudan Medical College and found Professor Guo who is engaged in oncology medical technology research.

"Old Guo, Lao Guo, please take a look at this paper."

Professor He shouted and raised the information in his hand at Professor Guo.

"paper?"

Professor Guo from the tumor laboratory looked up at Professor He, "Old He, you are so excited, is this paper still a little bit more valuable?"
To be continued...